Kev Tshawb Fawb Kev Tshawb Fawb Txog Kev Tshawb Fawb: PCR-bory ntshav ctdna Methylation Technology Qhib lub sijhawm tshiab ntawm MRD kev soj ntsuam mob cancer

Tsis ntev los no, Jama oncology (yog 33.012) Luam tawm cov kev koom tes nrog Kunyuan Methylation thiab pheej hmoo stratification) ". Qhov kev kawm no yog thawj qhov kev kawm paub txog kev ua haujlwm ntawm Methylation thiab kev soj ntsuam ntau dua, thiab txhim kho cov neeg mob muaj txiaj ntsig ntau dua thiab lub neej zoo. Txoj kev tshawb no tseem tau siv los ntawm phau ntawv Journes thiab nws cov kws kho vajtse pom zoo nyob rau hauv cov chaw tseem ceeb no, thiab xibfwb Ajay Oil los ntawm Tebchaws Meskas tau raug caw los saib xyuas nws. Txoj kev tshawb no kuj tau tshaj tawm los ntawm Genomeweb, ua cov xov xwm biomedical hauv Tebchaws Meskas.

Cancerectal Cancer (CRC) yog ib qho kev ua qog ib txwm muaj ntawm lub plab zom mov ntawm lub plab zom mov hauv Suav teb. 2020 Lub Koom Haum Thoob Ntiaj Teb rau Kev Tshawb Fawb Txog Kev Tshawb Xyuas ntawm Cancer (IRC) Cov Ntaub Ntawv Qhia Tias 5855,000 tus mob hauv ntiaj teb no, nrog cov mob cancer thib ob hauv Suav; 286,000 tus as-khauj cov nyiaj txog li 1/3 ntawm lub ntiaj teb, qeb duas uas muaj feem cuam tshuam rau kev tuag taus hauv Suav teb. Qhov tsib ua rau kev tuag hauv Suav teb. Nws yog qhov tsis tseem ceeb uas ntawm cov neeg mob, TNM Theem I, II, III thiab IV yog 18.6%, 30.7% feem. Ntau tshaj 80% ntawm cov neeg mob nyob hauv nruab nrab thiab 44% ntawm lawv tau ua rau lub siab thiab mob ntsws, raug mob hnyav thiab kev lag luam hnyav. Raws li cov txheeb cais ntawm National Cancer Center, kev nce qib qis dua hauv ib xyoos kev kuaj mob hauv ib xyoos ib zaug tuaj yeem siv sijhawm 60% ntawm cov nyiaj tau los ntawm tsev neeg. Cov neeg mob cancer yog kev txom nyem los ntawm tus kabmob thiab tseem muaj kev lag luam ntau [2].
Cij caum feem pua ​​ntawm cov mob qog noj ntshav cancect cancer yuav raug tshem tawm, tab sis cov qog ua haujlwm tas li, tab sis kev rov ua dua ntawm tsib lub xyoo dhau los tseem muaj txog 30%. Tus kabmob tsib xyoos los ntawm Cancer Cancer hauv Suav teb yog 90.1, 7,4% rau theem I, II, III thiab IV, feem.
Tsawg tsawg tus kab mob (MRD) yog qhov tseem ceeb ua rau mob qog rov qab dua tom qab kev kho mob qog. Xyoo tsis ntev los no, MRD nrhiav kev siv tshuab rau cov tub ntxhais kawm tau paub meej tias MRD kev pheej hmoo ntawm kev pheej hmoo ntawm Colorperative kev rov qab los ntawm Colorperatal Cancer. CTDNA kuaj muaj qhov zoo ntawm kev ua tsis tau ua, yooj yim, nrog cov hnoos qeev kom sai thiab kov yeej cov roj av hearnogeneity.
USCCN cov lus qhia rau tus mob hnyuv thiab cov ntaub ntawv kuaj mob CSOCTATING Txawm li cas los xij, feem ntau cov kev tshawb fawb txog CTDA hloov raws li cov txheej txheem ntau, thiab tus nqi qis heev, thiab tus nqi ntau ntawm cov neeg mob qog nqaij hlav.
Nyob rau hauv cov ntaub ntawv ntawm theem III Colorectal cov neeg mob qog nqaij hlav cancer, NGS-based CTDNA cov nqi kev saib xyuas txog li $ 10,000 rau ib lub sijhawm mus xyuas thiab xav tau lub sijhawm tos txog li ob lub lis piam. Nrog rau kev ntsuas methylation ntau hauv txoj kev tshawb fawb no, Contails tuaj yeem saib xyuas lub kaum ntawm tus nqi thiab tau txais ib daim ntawv tshaj tawm tsawg li ob hnub.
Raws li 560,000 tus mob cancer tshiab hauv Suav teb txhua xyoo, tom qab ntawv cov neeg ua lag luam yog kwv yees li ntawm tus mob cancere ntawm Millions tus neeg txhua xyoo.
Nws tuaj yeem pom tau tias cov txiaj ntsig kev tshawb fawb muaj cov kev tshawb fawb tseem ceeb thiab qhov tseem ceeb tshaj plaws. Los ntawm kev loj-teev cov kev tshawb fawb kev soj ntsuam, nws tau lees paub tias pethylene kev rov qab kho mob qog nqaij hlav kom tau txais tshuaj kho mob kom tau txais txiaj ntsig ntau dua cov neeg mob cancer ntau. Txoj kev tshawb no yog ua raws li Tebchaws Methaq®, ntau-noob caj noob metylation rau kev kuaj mob cancer uas muaj kev soj ntsuam thaum ntxov thiab kuaj mob tau lees paub los ntawm kev tshawb fawb hauv nruab nrab.
Gastroenterology (iF33.88), Lub tsev kho mob zoo tshaj plaws ntawm Flatain University, uas yog kev txheeb xyuas cov qog noj ntshav hauv ZHongiq in and and thiab lwm yam kev paub txog mob qog nqaij hlav cancer, thiab pib Tshawb nrhiav nws kuj tshawb nrhiav cov peev xwm thov hauv kev soj ntsuam mob qog nqaij hlav cancer.

Txhawm rau txuas ntxiv cov kev kho mob ntawm CTDA methylation muaj cov kabmob I-III suav nrog kev phais mob I-III suav nrog kev phais mob I-III suav nrog kev phais mob I-III ntshav CTDNA kuaj.
Ua ntej, nws tau pom tias CTDNA kev kuaj mob tuaj yeem twv tau kev pheej hmoo ntawm cov neeg mob qog nqaij hlav cancer thaum ntxov, ob qho tib si preposteratively. Preperative CTDNA-cov neeg mob Ctdna muaj qhov tshwm sim siab dua ntawm kev rov qab los dua li cov neeg mob ctdna-tsis zoo>). Thaum Ntxov PostOperative CTDNING tseem twv kev rov tshwm sim: ib hlis tom qab resection, Ctdna Radical, CTDNA-zoo yuav rov qab dua cov neeg mob tsis zoo; Pab neeg no tseem pom tias ua ke sim ua ke txhim kho kev ua tau zoo dua qub hauv CTDNA (AUC = tsis tseem ceeb piv rau CTDNA ib leeg (AUC = 0.839).
Cov chaw kho mob staging ua ke nrog cov kev pheej hmoo yog tam sim no lub hauv paus tseem ceeb tshaj plaws ntawm kev kho mob cancer tam sim no thiab nyob hauv tsev kho mob. Raws li qhov no, pab pawg neeg cov neeg mob uas cov neeg mob kheesxaws theem III cancer interes (T4 / N2) thiab muaj kev pheej hmoo siab (T1-3n1). Kev tshawb xyuas pom tias cov neeg mob hnyav ntawm cov neeg mob hnyav ntawm CTDNA-cov neeg mob muaj kev rov ua dua yog tias lawv tau txais rau lub hlis uas yuav raug tsim txom; Hauv cov tub rog qis ntawm CTDNA-cov neeg mob, tsis muaj qhov sib txawv ntawm kev ua kom zoo nkauj thiab cov txiaj ntsig tus neeg mob; Thaum cov neeg mob ctdna tsis muaj qhov zoo dua li qhov ua tau zoo dua li ctdna-tus neeg mob rov qab ua dua tshiab (RFS); Theem I thiab Tsawg-yuav muaj hmoo Theem II Colortical Cancer Txhua ctdna-cov neeg mob tsis zoo tsis muaj kev rov muaj dua li ob xyoos; Yog li no, kev sib koom ua ke ntawm CTDNA nrog cov tshuaj kuaj mob yuav tsum tau ua kom muaj kev pheej hmoo ua kom muaj kev phom sij thiab rov qab ua dua.

Daim duab 1. Ntshav CTDNA tsom xam ntawm POM1 rau thaum ntxov kuaj pom ntawm Colorensal Kev Xam Puam Mob Hlob
Cov txiaj ntsig ntxiv ntawm kev ntsuas CTDNAamic CTDNAs uas tau kuaj dua tshiab yog qhov ua rau mob qog nqaij daim duab rov qab los txog rau 20 lub hlis ntxov dua Kev kuaj pom ntawm cov kab mob rov ua dua thiab muaj kev cuam tshuam raws sijhawm.

Daim duab 2. CTDNA tsom xam raws li kev ntsuas ntev los xyuas cov xim tsis muaj txiaj ntsig

"Muaj ntau cov kev kawm ua tshuaj ntau hauv cov qog nqaij hlav cancer coj cov kev qhuab qhia ntawm cov kev tswj hwm kev sib tw, tshwj xeeb yog kev txiav txim siab kho mob thiab kev tawm tsam kev kho mob thiab kev kho mob thaum ntxov.

Qhov zoo dua ntawm kev xaiv methylation raws li kev sib hloov ntawm cov nqaij mos los ntawm cov nqaij mos, thiab tsis muaj kab mob qog nqaij hlav, thiab tsis txhob muaj kab mob qog nqaij hlav, thiab cov kab mob hematopoiesis.
Qhov kev kawm no thiab lwm cov kev tshawb fawb ntsig txog kev ntsuas MRD yog qhov kev pheej hmoo ua mob rau tus mob MRD yog qhov kev phais mob uas tseem ceeb tshaj plaws tom qab kev phais mob I-III cancer.
Daim teb ntawm MRD tab tom nrawm nrawm nrawm nrog tus lej ntawm lub tswv yim tshiab, muaj kev pom zoo thiab cov tshuaj tiv thaiv kev ua kom sib haum xeeb (ultra-close sib txawv ua ntu zus lossis tag nrho cov kev sib tw. Peb cia siab tias Vagaiiq® txuas ntxiv mus kawm cov tshuaj ntsuam uas MRD uas muaj peev xwm sib txuas lus, kev pheej hmoo siab thiab tuaj yeem siv dav hauv kev coj ua. "
Ntawv Sawv cev
[1] Mo S, YE L, WANT S, HAN L, WANG H, LAJ DUA NTAWM MOLECATE REASE Cancer ntawm Kev Qaum Qaum Da Metylation. Jama oncol. 2023 Apr 20.
[2] "Lub nra hnyav ntawm tus kab mob cancera cancer hauv Suav Tebchaws Suav: Nws puas tau hloov xyoo tsis ntev los no? , Suav phau ntawv ceev xwm ntawm Epidemiology, vol. 41, Tsis muaj. 10, Kaum Hli 2020.
[3] TARZAGA N, Gimeno-Valiente F, Gambardella V, li al. Hom Phiaj Tom ntej-Generation Sutsencing ntawm Circulating-qog DNA rau kev taug qab cov kab mob tsis txaus ntseeg hauv cov neeg muaj mob hauv ib cheeb tsam. Ann AceCol. Nov 1, 2019; 30 (11): 1804-1812.
[4] Taieb J, Anduc T, Auclin E. Refining AdmireT Kev Kho Mob Tus Mob Tsis Yog Tus Qauv Nyog, Cov Qauv Qauv Tshiab thiab Kev Pom Zoo. Cancer kho Rev. 2019; 75: 1-11.