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Peking University's Yunlong Cao tau tso npe rau kev tshawb fawb txog tus kabmob tshiab

Thaum Lub Kaum Ob Hlis 15, 2022, Nature tau tshaj tawm nws Nature's 10, ib daim ntawv teev npe ntawm kaum tus neeg uas tau ua ib feem ntawm lub xyoo cov xwm txheej tseem ceeb ntawm kev tshawb fawb, thiab nws cov dab neeg muaj kev pom tshwj xeeb rau qee qhov xwm txheej tseem ceeb tshaj plaws ntawm xyoo no.

Hauv ib xyoos ntawm kev kub ntxhov thiab kev tshawb pom zoo siab, Xwm tau xaiv kaum tus neeg los ntawm cov kws tshawb fawb hnub qub uas tau pab peb nkag siab txog lub ntiaj teb txoj kev nyob deb tshaj plaws, rau cov kws tshawb fawb uas tau ua cov cuab yeej cuab tam hauv New Crown thiab mob khaub thuas mob khaub thuas, rau cov kws phais neeg uas tau rhuav tshem cov kev txwv ntawm kev hloov pauv hauv nruab nrog cev. , hais tias Rich Monastersky, editor-in-chief ntawm Nature Features.

Yunlong Cao yog los ntawm Biomedical Frontier Innovation Center (BIOPIC) ntawm Peking University. Dr. Cao kawm tiav hauv Zhejiang University nrog Bachelor's degree hauv Physics thiab tau txais nws PhD los ntawm Harvard University's Department of Chemistry thiab Chemical Biology nyob rau hauv Xiaoliang Xie, thiab tam sim no yog Tus Kws Tshawb Fawb Kev Tshawb Fawb ntawm Biomedical Frontier Innovation Center ntawm Peking University. Yunlong Cao tau tsom mus rau kev txhim kho cov thev naus laus zis ib leeg ib leeg, thiab nws txoj kev tshawb fawb tau pab taug qab cov kev hloov pauv ntawm tus kabmob tshiab no thiab kwv yees qee qhov kev hloov pauv uas ua rau tsim cov kabmob tshiab.

Nyob rau 18 May 2020, Xiaoliang Xie/Yunlong Cao et al. luam tawm ib daim ntawv nyob rau hauv phau ntawv journal Cell txoj cai: "Potent neutralizing antibodies tiv thaiv SARS-CoV-2 txheeb xyuas los ntawm high-throughput single-cell sequencing ntawm convalescent cov neeg mob 'B hlwb" Cov ntaub ntawv tshawb fawb.

Txoj kev tshawb no qhia txog cov txiaj ntsig ntawm tus kabmob tshiab (SARS-CoV-2) neutralizing tshuaj tiv thaiv kab mob, uas tau siv lub siab dhau los ntawm ib leeg-cell RNA thiab VDJ sequencing platform los txheeb xyuas 14 cov tshuaj tiv thaiv monoclonal los ntawm ntau dua 8500 antigen-bound IgG1 antibodies hauv 60 tus neeg mob tau zoo los ntawm COVID-19.

Txoj kev tshawb no pom tau tias thawj zaug uas kev sib txuas ntawm ib leeg-cell sib luag tuaj yeem siv ncaj qha rau kev tshawb nrhiav tshuaj thiab muaj qhov zoo ntawm kev ua cov txheej txheem sai thiab muaj txiaj ntsig, uas cog lus tias yuav hloov pauv txoj hauv kev uas tib neeg tshuaj ntsuam rau cov tshuaj tiv thaiv kab mob sib kis.

Thaum Lub Rau Hli 17, 2022, Xiaoliang Xie/Yunlong Cao et al. luam tawm ib daim ntawv muaj cai: BA.2.12.1, BA.4 thiab BA.5 khiav tawm cov tshuaj tiv thaiv kab mob elicited los ntawm Omicron kab mob hauv phau ntawv journal Nature.

Txoj kev tshawb no pom tias cov subtypes tshiab ntawm Omicron mutant strains BA.2.12.1, BA.4 thiab BA.5 tau pom tias muaj zog tiv thaiv kab mob thiab muaj kev cuam tshuam tseem ceeb ntawm cov ntshav khiav tawm hauv cov neeg mob Omicron BA.1 zoo.

Cov kev tshawb pom no qhia tias BA.1-based Omicron tshuaj tiv thaiv tej zaum yuav tsis tsim nyog los ua ib qho tshuaj tiv thaiv kab mob tam sim no thiab tias cov tshuaj tiv thaiv kab mob induced yuav tsis muab broad-spectrum tiv thaiv tus kab mob tshiab. Tsis tas li ntawd, kev tiv thaiv tsiaj txhu los ntawm kev kis kab mob Omicron yog qhov nyuaj heev kom ua tiav vim qhov 'immunogenic' tshwm sim ntawm tus mob coronaviruses tshiab thiab kev hloov pauv sai ntawm cov chaw tiv thaiv kev hloov pauv.

Thaum Lub Kaum Hli 30, 2022, Pab Pawg Xiaoliang Xie/Yunlong Cao tau tshaj tawm cov ntawv tshawb fawb muaj npe: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution in the preprint bioRxiv.

Txoj kev tshawb no qhia tau hais tias qhov zoo ntawm XBB dhau BQ.1 yuav yog vim ib feem ntawm kev hloov pauv sab nraud ntawm receptor binding domain (RBD) ntawm spinosin, tias XBB kuj muaj kev hloov pauv hauv qee qhov ntawm genome encoding N-terminal structural domain (NTD. ) ntawm cov spinosin, thiab tias XBB muaj peev xwm khiav tawm cov tshuaj tiv thaiv kab mob tiv thaiv NTD, uas tuaj yeem tso cai rau cov neeg tiv thaiv kab mob BQ.1. thiab lwm yam subtypes. Txawm li cas los xij, nws tsim nyog sau cia tias kev hloov pauv hauv cheeb tsam NTD tau tshwm sim hauv BQ.1 ntawm tus nqi nrawm heev. Cov kev hloov pauv no ua rau muaj peev xwm ntawm cov kev hloov pauv no kom dim ntawm cov tshuaj tiv thaiv kab mob uas tsim los ntawm kev txhaj tshuaj tiv thaiv thiab kab mob yav dhau los.

Dr. Yunlong Cao tau hais tias tej zaum yuav muaj qee qhov kev tiv thaiv XBB yog tias kis BQ.1, tab sis xav tau kev tshawb fawb ntxiv los muab pov thawj rau qhov no.

Ntxiv rau Yunlong Cao, ob tus neeg tau ua npe rau lawv cov kev pabcuam zoo rau kev noj qab haus huv thoob ntiaj teb, Lisa McCorkell thiab Dimie Ogoina.

Lisa McCorkell yog tus kws tshawb fawb nrog Long COVID thiab ua tus tsim tswv cuab ntawm Patient-Led Research Collaborative, nws tau pab txhawb kev paub thiab nyiaj txiag rau kev tshawb fawb txog tus kab mob.

Dimie Ogoina yog tus kws kho mob kis kab mob ntawm Niger Delta University hauv Nigeria thiab nws txoj haujlwm ntawm tus kab mob ntshav liab hauv Nigeria tau muab cov ntaub ntawv tseem ceeb hauv kev tawm tsam tus kab mob liab.

Thaum Lub Ib Hlis 10, 2022, Lub Tsev Kawm Ntawv ntawm Maryland Tsev Kawm Ntawv Tshuaj tau tshaj tawm lub ntiaj teb thawj qhov kev vam meej gene-edited npua lub plawv cog rau hauv tus neeg muaj sia nyob, thaum tus neeg mob plawv 57 xyoo David Bennett tau txais cov noob hloov pauv lub plawv los cawm nws txoj sia. .

Txawm hais tias lub siab npua no tsuas yog txuas ntxiv David Bennett lub neej los ntawm ob lub hlis, nws tau ua tiav zoo thiab muaj keeb kwm kev ua tiav hauv thaj chaw xenotransplantation. Muhammad Mohiuddin, tus kws phais neeg uas tau coj pab pawg ua tiav qhov kev hloov pauv ntawm tib neeg ntawm lub siab hloov pauv caj ces, tau raug hu ua Nature's Top 10 Cov Neeg ntawm Lub Xyoo.

Ob peb lwm tus tau raug xaiv los ua kom muaj txiaj ntsig zoo tshaj plaws ntawm kev tshawb fawb thiab kev txhim kho tseem ceeb ntawm txoj cai, suav nrog astronomer Jane Rigby ntawm NASA's Goddard Space Center, uas tau ua lub luag haujlwm tseem ceeb hauv Webb Space Telescope lub luag haujlwm kom tau lub koob yees duab mus rau hauv qhov chaw thiab ua haujlwm kom zoo, coj tib neeg lub peev xwm los tshawb nrhiav. lub ntiaj teb mus rau qib tshiab thiab siab dua. alondra Nelson, uas yog US Science thiab Technology Policy Tus Thawj Coj ntawm Lub Chaw Haujlwm Saib Xyuas Kev Tshawb Fawb thiab thev naus laus zis, tau pab kev tswj hwm ntawm Thawj Tswj Hwm Biden tsim cov ntsiab lus tseem ceeb ntawm nws cov txheej txheem kev tshawb fawb, suav nrog txoj cai ntawm kev ncaj ncees ntawm kev tshawb fawb thiab cov lus qhia tshiab ntawm kev qhib kev tshawb fawb. Diana Greene Foster, tus kws tshawb fawb txog kev rho menyuam tawm thiab tus kws saib xyuas pej xeem ntawm University of California, San Francisco, tau muab cov ntaub ntawv tseem ceeb ntawm qhov kev xav tau ntawm US Supreme Court qhov kev txiav txim siab thim txoj cai tiv thaiv kev rho menyuam tawm.

Kuj tseem muaj cov npe nyob rau xyoo no cov npe saum toj kawg nkaus uas cuam tshuam rau kev txhim kho kev hloov pauv huab cua thiab lwm yam kev kub ntxhov thoob ntiaj teb. Lawv yog: António Guterres, Secretary-General ntawm United Nations, Saleemul Huq, Tus Thawj Coj ntawm International Center for Climate Change and Development hauv Dhaka, Bangladesh, thiab Svitlana Krakovska, Tus Thawj Coj ntawm Ukrainian delegation rau UN Intergovernmental Panel ntawm Kev Nyab Xeeb Kev Hloov ( IPCC).