Kaum Tus Neeg Zoo Tshaj Plaws hauv Kev Tshawb Fawb Txog Xwm:

Peking University tus Yunlong Cao raug xaiv los ua tus tshawb fawb txog tus kab mob coronavirus tshiab

Thaum Lub Kaum Ob Hlis 15, 2022, Nature tau tshaj tawm nws Nature's 10, daim ntawv teev npe ntawm kaum tus neeg uas tau yog ib feem ntawm cov xwm txheej tseem ceeb ntawm kev tshawb fawb hauv xyoo, thiab lawv cov dab neeg muab kev xav tshwj xeeb rau qee qhov xwm txheej tseem ceeb tshaj plaws ntawm lub xyoo tshwj xeeb no.

Hauv ib xyoos ntawm kev kub ntxhov thiab kev tshawb pom zoo siab, Xwm tau xaiv kaum tus neeg los ntawm cov kws tshawb fawb txog hnub qub uas tau pab peb nkag siab txog lub ntiaj teb deb tshaj plaws, rau cov kws tshawb fawb uas tau ua lub luag haujlwm tseem ceeb hauv New Crown thiab monkeypox kis thoob plaws, rau cov kws phais neeg uas tau ua txhaum txoj cai ntawm kev hloov pauv lub cev, Rich Monastersky, tus thawj coj ntawm Nature Features hais.

Yunlong Cao yog los ntawm Biomedical Frontier Innovation Center (BIOPIC) ntawm Peking University. Dr. Cao kawm tiav ntawm Zhejiang University nrog rau daim Bachelor's degree hauv Physics thiab tau txais nws daim PhD los ntawm Harvard University's Department of Chemistry thiab Chemical Biology hauv Xiaoliang Xie, thiab tam sim no yog tus Research Associate ntawm Biomedical Frontier Innovation Center ntawm Peking University. Yunlong Cao tau tsom mus rau kev tsim cov thev naus laus zis ib lub cell sequencing, thiab nws txoj kev tshawb fawb tau pab taug qab kev hloov pauv ntawm cov kab mob coronavirus tshiab thiab kwv yees qee qhov kev hloov pauv uas ua rau muaj cov kab mob hloov pauv tshiab.

Thaum Lub Tsib Hlis 18, 2020, Xiaoliang Xie/Yunlong Cao et al. tau luam tawm ib daim ntawv hauv phau ntawv xov xwm Cell hu ua: "Cov tshuaj tua kab mob muaj zog tiv thaiv SARS-CoV-2 uas tau txheeb xyuas los ntawm kev ua tiav ntawm cov hlwb ib leeg ntawm cov neeg mob uas tau rov zoo los ntawm cov hlwb B" Daim ntawv tshawb fawb.

Daim ntawv tshawb fawb no qhia txog cov txiaj ntsig ntawm kev tshuaj ntsuam kab mob coronavirus tshiab (SARS-CoV-2), uas siv lub platform high-throughput single-cell RNA thiab VDJ sequencing los txheeb xyuas 14 lub monoclonal antibodies uas tsis muaj zog los ntawm ntau dua 8500 antigen-bound IgG1 antibodies hauv 60 tus neeg mob COVID-19 uas tau zoo.

Txoj kev tshawb fawb no qhia thawj zaug tias kev siv high-throughput ib lub cell sequencing tuaj yeem siv ncaj qha rau kev tshawb nrhiav tshuaj thiab muaj qhov zoo ntawm kev ua ib qho txheej txheem sai thiab zoo, uas cog lus tias yuav hloov pauv txoj hauv kev uas tib neeg tshuaj xyuas cov tshuaj tiv thaiv kab mob rau cov kab mob sib kis.

Thaum Lub Rau Hli 17, 2022, Xiaoliang Xie/Yunlong Cao et al. tau luam tawm ib daim ntawv hu ua: BA.2.12.1, BA.4 thiab BA.5 cov tshuaj tiv thaiv kab mob uas tau los ntawm kev kis kab mob Omicron hauv phau ntawv xov xwm Nature.

Txoj kev tshawb fawb no pom tau tias cov subtypes tshiab ntawm Omicron mutant strains BA.2.12.1, BA.4 thiab BA.5 tau qhia txog kev tiv thaiv kab mob ntau ntxiv thiab kev tsis ua rau cov plasma escape hauv cov neeg mob uas tau zoo los ntawm Omicron BA.1.

Cov kev tshawb pom no qhia tau hais tias cov tshuaj tiv thaiv kab mob Omicron uas siv BA.1 yuav tsis tsim nyog ua ib qho tshuaj txhawb nqa hauv cov ntsiab lus tam sim no thiab cov tshuaj tiv thaiv kab mob uas tsim los yuav tsis muab kev tiv thaiv dav dav tiv thaiv cov kab mob hloov pauv tshiab. Ntxiv mus, kev tiv thaiv kab mob los ntawm kev kis tus kab mob Omicron nyuaj heev rau kev ua tiav vim yog qhov tshwm sim 'immunogenic' ntawm cov kab mob coronaviruses tshiab thiab kev hloov pauv sai ntawm cov chaw hloov pauv ntawm lub cev tiv thaiv kab mob.

Thaum Lub Kaum Hli Ntuj hnub tim 30, xyoo 2022, pab neeg ntawm Xiaoliang Xie/Yunlong Cao tau luam tawm ib daim ntawv tshawb fawb hu ua: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution in the preprint bioRxiv.

Daim kev tshawb fawb no qhia tau hais tias qhov zoo ntawm XBB dua BQ.1 tej zaum yuav yog vim muaj kev hloov pauv sab nraud ntawm lub receptor binding domain (RBD) ntawm spinosin, tias XBB kuj muaj kev hloov pauv hauv qee qhov ntawm genome uas encoding N-terminal structural domain (NTD) ntawm spinosin, thiab tias XBB muaj peev xwm dim ntawm cov tshuaj tiv thaiv kab mob tiv thaiv NTD, uas yuav ua rau nws kis tau rau cov neeg uas tsis muaj zog rau BQ.1 thiab lwm yam subtypes. Txawm li cas los xij, nws tsim nyog sau cia tias kev hloov pauv hauv thaj tsam NTD tshwm sim hauv BQ.1 ntawm qhov nrawm heev. Cov kev hloov pauv no ua rau muaj peev xwm ntawm cov variants no kom dim ntawm cov tshuaj tiv thaiv kab mob uas tsim los ntawm kev txhaj tshuaj thiab kev kis kab mob yav dhau los.

Dr. Yunlong Cao tau hais tias tej zaum yuav muaj qee yam kev tiv thaiv tiv thaiv XBB yog tias muaj tus kab mob BQ.1, tab sis yuav tsum tau tshawb nrhiav ntxiv kom muab pov thawj rau qhov no.

Ntxiv rau Yunlong Cao, muaj ob tug neeg ntxiv tau raug xaiv los ua cov neeg muaj npe nrov rau lawv cov kev pab cuam zoo tshaj plaws rau cov teeb meem kev noj qab haus huv thoob ntiaj teb, Lisa McCorkell thiab Dimie Ogoina.

Lisa McCorkell yog ib tug kws tshawb fawb nrog Long COVID thiab ua ib tug tswv cuab ntawm Patient-Led Research Collaborative, nws tau pab tsa kev paub thiab nyiaj txiag rau kev tshawb fawb txog tus kab mob.

Dimie Ogoina yog ib tug kws kho mob kis kab mob ntawm Niger Delta University hauv Nigeria thiab nws txoj haujlwm txog kev sib kis kab mob monkeypox hauv Nigeria tau muab cov ntaub ntawv tseem ceeb hauv kev sib ntaus sib tua kev sib kis kab mob monkeypox.

Thaum Lub Ib Hlis 10, 2022, Tsev Kawm Ntawv Qib Siab University of Maryland School of Medicine tau tshaj tawm thawj zaug kev cog lub plawv npua uas tau hloov kho gene hauv tib neeg uas muaj sia nyob, thaum tus neeg mob plawv hnub nyoog 57 xyoo David Bennett tau txais kev hloov pauv lub plawv npua uas tau hloov kho gene los cawm nws txoj sia.

Txawm hais tias lub plawv npua no tsuas yog ua rau David Bennett lub neej ntev dua ob lub hlis xwb, nws tau ua tiav zoo heev thiab yog ib qho keeb kwm tseem ceeb hauv kev hloov pauv neeg lub cev. Muhammad Mohiuddin, tus kws phais uas tau coj pab pawg neeg uas ua tiav qhov kev hloov pauv tib neeg ntawm lub plawv npua uas tau kho caj ces, tau raug xaiv los ua tus neeg tseem ceeb hauv Nature's Top 10 People of the Year list.

Muaj ob peb tug neeg ntxiv raug xaiv los txhawb nqa kev ua tiav zoo kawg nkaus hauv kev tshawb fawb thiab kev nce qib tseem ceeb ntawm txoj cai, suav nrog tus kws tshawb fawb txog hnub qub Jane Rigby ntawm NASA's Goddard Space Center, uas tau ua lub luag haujlwm tseem ceeb hauv Webb Space Telescope lub hom phiaj kom coj lub tsom iav mus rau hauv qhov chaw thiab ua haujlwm kom raug, coj tib neeg lub peev xwm los tshawb nrhiav lub ntiaj teb mus rau qib tshiab thiab siab dua. alondra Nelson, ua tus Thawj Coj Ua Haujlwm ntawm US Science thiab Technology Policy ntawm Office of Science and Technology, tau pab tsoomfwv ntawm Thawj Tswj Hwm Biden tsim cov ntsiab lus tseem ceeb ntawm nws cov txheej txheem kev tshawb fawb, suav nrog txoj cai ntawm kev ncaj ncees ntawm kev tshawb fawb thiab cov lus qhia tshiab ntawm kev tshawb fawb qhib. Diana Greene Foster, tus kws tshawb fawb txog kev rho menyuam thiab tus kws tshawb fawb txog pej xeem ntawm University of California, San Francisco, tau muab cov ntaub ntawv tseem ceeb ntawm qhov cuam tshuam ntawm US Supreme Court qhov kev txiav txim siab los thim rov qab kev tiv thaiv kev cai lij choj rau cov cai rho menyuam.

Tseem muaj cov npe nyob rau hauv daim ntawv teev npe kaum sab saum toj xyoo no uas muaj feem cuam tshuam rau kev hloov pauv huab cua thiab lwm yam teeb meem thoob ntiaj teb. Lawv yog: António Guterres, Tus Tuav Ntaub Ntawv ntawm United Nations, Saleemul Huq, Tus Thawj Coj ntawm Lub Chaw Thoob Ntiaj Teb rau Kev Hloov Pauv Huab Cua thiab Kev Txhim Kho hauv Dhaka, Bangladesh, thiab Svitlana Krakovska, Tus Thawj Coj ntawm pawg neeg sawv cev Ukraine rau UN Intergovernmental Panel on Climate Change (IPCC).