Theem III cov ntaub ntawv nyob rau Tuam Tshoj txoj kev siv tshuaj ntsuab tshiab hauv Nejm qhia kev ua tau zoo rau Paxlovid

Hauv lub sijhawm thaum ntxov ntawm 29 Hlis ntuj nqeg ,, moos tau tshaj tawm online ntawm cov theem tshiab III kawm txog Suav Coronavirus tshiab. Cov txiaj ntsig tau pom tias VV116 tsis muaj kev phem dua li paxlovid (nematovir / ritonavir / ritonavir / ritonavir) nyob rau hauv cov nqe lus ntawm kev kho mob rov qab thiab muaj tsawg zog.

Cov Duab Seem: NejM

Median rov qab lub sijhawm 4 hnub, kev tshwm sim tsis zoo 67.4%

VV116 yog ib qho tshuaj nucleoside anti-tshiab Coronavirus (SARS-CORENE-FANGE

Xyoo 2021, ib theem II kev sim tshuaj ntsuam ntawm VV116 tau ua tiav hauv Uzbekistan. Cov txiaj ntsig ntawm txoj kev tshawb nrhiav tau qhia tias VV116 pab pawg yuav tau zoo dua txhim kho cov tsos mob hauv tsev kho mob thiab txo txoj kev pheej hmoo ntawm cov txheej txheem tseem ceeb thiab kev tuag piv rau pawg tswj hwm. Raws li cov txiaj ntsig zoo ntawm qhov kev sim siab no

Cov theem III kev kho mob [2] (NCT05341609), LED los ntawm Prof. Zhao Guang ntawm Shanghai Tsev kho mob Renijin, tau ua tiav thaum muaj kev tawm ntawm OmicDo variant ( B.1.1.529) txij lub Peb Hlis mus txog lub Tsib Hlis hauv Shanghai, nrog lub hom phiaj ntawm kev ntsuas tus Kev ua tau zoo thiab kev nyab xeeb ntawm VV116 tiv thaiv paxlovid rau kev kho thaum ntxov ntawm cov neeg mob uas muaj mob me rau kev sib cav-19. Lub hom phiaj yog txhawm rau ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm VV116 tiv thaiv jaxlovid rau kev kho mob thaum ntxov ntawm cov tubid-19.

Cov Duab Tau: Siv 2

Xws li cov neeg dig muag-dig muag, randomized, tswj hwm tau ntawm 4 Lub Plaub Hlis thiab nrog cov neeg muaj feem ua haujlwm ntawm cov neeg koom nrog ntawm xya lub tsev kho mob hauv Shanghai, Suav Teb. Thaum kawg, 771 cov neeg koom tau txais yog VV116 (300 MG txhua 12 teev nyob rau hnub 1 thiab 300 mg nimatuvir + 100 mg ritonavir + txhua 12 teev rau 5 hnub) raws li Tshuaj noj tej noj.

Cov txiaj ntsig kev tshawb fawb no tau qhia tias kev kho mob me me rau kev kho mob hauv tsev kho mob) kwv yees los ntawm cov kws kho mob rov qab yog 4 hnub hauv VV116 pawg thiab 5 Hnub nyob rau hauv pab pawg paxlovid (kev phom sij sib piv, 1.17; 95% ci, 1.02 txog 1.36;> 0.8).

Saib xyuas kev kho mob lub sijhawm

Thawj thiab thib ob ua tau zoo kawg nkaus kawg nkaus (tsom xam cov pej xeem)

Cov Duab Tau: Siv 2

Hais txog kev nyab xeeb, cov neeg koom nrog tau txais VV116 qhia tawm tsawg dua cov xwm txheej (77.3%) ntawm 28-hnub tsis zoo yog qis rau vv116 (2.6% ) dua li paxlovid (5.7%).

Cov kev sib raug zoo (cov neeg muaj kev nyab xeeb)

Cov Duab Tau: Siv 2

Kev sib cav thiab cov lus nug

Lub Tsib Hlis 23, 2022, Juniper nthuav tawm tias theem kev kawm tua hluav taws rau kev kho mob me me mus rau kev kawm me me mus rau kev kawm me me rau kev kawm kom tsawg

Cov Duab Tau: Siv 1

Lub sijhawm uas cov ntsiab lus ntawm kev sim siab tau tsis muaj, kev sib cav ib puag ncig ntawm theem III kev kawm thiab, nws yog kev tswj hwm ib leeg, nws tau ntshai tias nws yuav nyuaj rau kev txiav txim cov tshuaj ua tiav; Thib ob, muaj lus nug txog kev soj ntsuam cov kev tshawb fawb.

Kev kuaj mob xam rau Juniper yog (i) Qhov txiaj ntsig zoo rau kev sim tshiab yas, thiab (III) cov neeg mob siab muaj feem mob hnyav-19, suav nrog kev tuag. Txawm li cas los xij, tsuas yog tsuas yog thawj lub vijtsam kuaj xyuas yog 'lub sijhawm los txhawb nqa kev kho mob kom rov zoo'.

Tsuas yog ua ntej tshaj tawm, rau Tsib Hlis 14, Juniper tau kho qhov kev hloov pauv ntawm cov kev hloov pauv kom muaj mob loj lossis tuag "[3].

Cov Duab Tau: Siv 1

Ob lub ntsiab lus tseem ceeb no tseem muaj kev sib cav los ntawm kev tshawb fawb no.

Vim yog kev tawm ntawm omicron, zus tau tej cov khoom sib txawv rau cov papeboid tsis tau ua tiav qhov kev sim no kom tsis muaj peev xwm ua ntej kev sim no siv ib qho dig muag ob zaug, tsim qauv ob-mock. Raws li rau tib-qhov muag tsis pom kev ntawm kev sim tshuaj, Juniper tau ua tiav txhais tau tias tsis muaj kev sib txuas lus ntxiv tias tsis yog tus kws tshawb fawb ntawm kev kawm xaus) tsis yog tus txhawb nqa yuav paub Qhov kev kho yeeb tshuaj tshwj xeeb tshuaj rau thaum lub database zaum kawg yog xauv qhov kawg ntawm kev kawm.

Txog rau lub sijhawm ntawm kev tsom xam zaum kawg, tsis muaj leej twg koom nrog kev sim tuag lossis muaj kev sib tw txog kev tiv thaiv kom tsis txhob muaj kev kub ntxhov los ntawm kev ua kom muaj kev loj hlob los yog tseem ceeb ntawm covid-19 lossis tuag. Cov ntaub ntawv qhia tias kwv yees li nruab nrab nruab nrab ntawm rustain retession ntawm covid-19 txog 8) hauv ob pab pawg (1.06; $91 txog 1.22) [2]. Nws tsis yog qhov nyuaj los piav txog vim li cas cov thawj qhov siab tshaj plaws ntawm kev hloov dua siab tshiab rau kev mob hnyav lossis kev tuag ', uas yog thaum xaus kev sim siab, raug tshem tawm.

Hnub nyoog 18 Lub Tsib Hlis 2022, cov ntawv xov xwm tawm microbes & kev kis tus kab mob sib txawv ntawm thawj zaug ntawm cov neeg mob

Cov ntaub ntawv los ntawm txoj kev tshawb no tau pom tias cov neeg mob Omictre Acid kuaj muaj lub sijhawm ua ntej ntawm cov 11,56 hnub, tsawg dua 11.13 hnub hauv pawg tswj. Kev tswj hwm ntawm VV116 rau cov neeg mob cov tsos mob hauv lub sijhawm no (2-10 hnub ntawm lub sijhawm nucleic acid) Hais txog kev nyab xeeb tshuaj, tsis muaj cov kev tsis zoo tshwm sim tau pom hauv VV116 pab pawg kho mob.

Cov Duab Tau: Siv 4

Muaj peb lub tsev kuaj mob sib txuas lus ntawm VV116, ob qho ntawm cov me iii kawm txog kev mob me txog rau hauv pawg Khiv-19 (NCT05242, NCT05582629). Lwm qhov kev sim rau kev mob hnyav rau kev kawm hnyav-19 yog kev kawm ob tog (NCT05279235) los ntsuas kev ua tau zoo thiab kev nyab xeeb ntawm VV116 piv rau kev kho mob. Raws li kev tshaj tawm los ntawm Juniper, thawj tus neeg mob tau cuv npe thiab dosed nyob rau lub Peb Hlis 2022.

Cov Duab Seem: ClialTrials.Gov

Tuaj txog::

[1] Jackshi Biotech: Tshaj Tawm ntawm lub ntsiab kawg taw tes ntawm theem III qhia txog kev kho mob hauv tsev kho mob ntawm kev kho mob hauv kev kho mob kom ntxov rau kev sib cav sib ceg-19

[2] https://www.nym.org.org.org.Qhov xwmtxhom_Home [3] https://clinaltrial.com/show/record/record/nct05341609 [4] Ensi ma, Jingwen Ai , Yi Zhang, Jianming Zheng, Xiaogang Gao, Jog yin, Zhiren Fu, Hao Dam, Linlin Xu, Yanpee Lv, Yanpee Lv, Zhijun Zhu, Wenhong Zhang, Zhengxin Wang. (2022) OmicDory kis tus kab mob profile thiab txhaj tshuaj tiv thaiv kab mob ntawm 1881 lub siab hloov pauv cov neeg tau txais: ib qho kev hloov pauv ntau yam li qub. Cov microbes tawm & kis tau tus mob 11: 1, Nplooj 2636-2644.